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Natural Remedies

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All-Natural Healing: St. John’s Wort

Many well-designed studies agree that for mild to moderate depression, St. John’s wort works, but does it stand up against prescription drugs like Prozac and Zoloft? Some studies say it does. A 2005 Cochrane study found that it is equally effective as some tricyclical antidepressants—and with fewer side effects. In the drug group, 23% reported agitation, upset stomach, dizziness, fatigue, anxiety, and sex problems. Among those taking St. John’s wort, only 8% described side effects, most often an upset stomach. Similar results have been found in a study comparing the herb with the drug Zoloft. But recent research from the National Institute of Mental Health warns that St. John’s wort isn’t much help when it comes to major depression, and it is not a proven therapy for depression in general. See your doctor if you suspect you are suffering from the disease.

Dosage: In most studies showing benefits, people were given 900 milligrams of the herb a day.

Caveats: St. John’s wort interacts with many medications, including birth control pills, possibly reducing their effectiveness, so talk to your physician or pharmacist before mixing meds with this or any other herb. Also, as with other life-threatening illnesses, don’t self-medicate depression; talk to your doctor first.

Last Updated: February 20, 2009
Filed Under: Natural Remedies
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Comments (3)

The following content represents the opinions of Health.com users. It is not editorially reviewed for medical or factual accuracy. It does not constitute medical advice. See your doctor for medical advice.
  • amanda

    I was drinking a Yogi bedtime tea to relax at night and after drinking it, I always felt nice and calm…I thought it was just the effects of my meditative thoughts while slowly sipping the warm brew…turns out it had a small dose of St. John’s Wart in it!!! if that was from the supplement, wow, it works lol. I stopped drinking it though to keep my bc up to par.

  • Tony D

    Thanks for a fair, but slightly shallow, evaluation of Vitamin C, Glucosamine/Chondroitin, Echinacea, and St. John’swort. What research studies check is one supplement at a time. This system is necessary for drugs but inadequate for food supplements, What research studies do not evaluate is that most supplements work best when used synergystically. For example, echinaces works better when used with vitamin C and single B vitamins work best when used with the entire B-complex.

  • Sateesh

    Please tell me more bout your sevices.

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