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What Women Need to Know About Painkillers

One size fits all does not apply to painkillers. “Women are not small men when it comes to pain treatment,” says Mark Allen Young, MD.

While many basic medications, from aspirin to Ben-Gay, work equally well in both genders, there are also significant differences. In particular, recent research shows that some of the anti-inflammatory pain drugs known as NSAIDs (ibuprofen and naproxen sodium) don’t always bring women the same level of relief they provide men.

And the more serious painkillers, known as opioids (codeine, morphine) often prescribed postsurgery or for short-term relief of extreme pain, cause many more side effects such as nausea, constipation, depression, and itching in women than men. Luckily, other drugs work particularly well for women.

Antidepressants
Used in lower doses than for psychological benefit, some antidepressants work on pain by “modulating the nerve feedback into the brain,” Young says. They’re prescribed for migraine prevention, fibromyalgia, and lower back pain.

Neuropathic pain relievers
The newest weapon in the pain-killing arsenal, pain relievers such as tramadol, ease irritable bowel syndrome and menstrual pain, probably because they desensitize nerves, says Neil Kirschen, MD, president of the American Association of Orthopedic Medicine.

Trigger-point injections
Used mainly for muscular pain in conditions such as fibromyalgia, trigger-point injections ease pain with lidocaine and other desensitizing drugs. An exciting breakthrough is ultrasound-guided injections, Young says, in which imaging helps place the medication exactly where it needs to go. Another treatment option is lidocaine patches.

Spinal epidurals
Used for sciatica, herniated disks, and other back problems, steroid injections or nerve blocks “block the pain cycle,” says Joseph Shurman, MD. They’re now used for other parts of the body, too.

The return of oxycontin
Celebrity addiction stories notwithstanding, this morphine-based painkiller is highly effective and not as addictive if used very carefully for a short period of time, on a case by case basis, Shurman says.

By Melanie Haiken

Last Updated: February 18, 2009
Filed Under: Everyday Health
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Comments (2)

The following content represents the opinions of Health.com users. It is not editorially reviewed for medical or factual accuracy. It does not constitute medical advice. See your doctor for medical advice.
  • Linda W. Deans, Ph.D

    It was comforting for me to “read” that antidepressants are sometimes used for pain because I was prescribed one for lower back pain by my physician. It really worked; however, I was concerned about the “psychological effect” that it may have. Great information and very timely for me.

  • betty brooks

    Question for Linda Deans
    What type of antidepressant were you described that helped you?

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